Glyoxalase 1 Protein Interaction Network
What is an Interaction Network?
Protein interaction networks are useful tools while studying a protein. Databases such as STRING compile information from published papers and experiments to map how and where proteins interact with each other in an organism. A protein rarely works alone, and by understanding the other proteins it comes in contact with or has similar function to, more can be understood about that protein itself.
Analysis and Discussion
Glyoxalase 1 interacts with an array of other enzymes, several of which also detoxify byproducts of normal body function. Some proteins of interest while observing GLO1 are those present in nervous tissue or impacting neuronal activity, possibly having an effect on anxiety. Others active in glucose metabolism may also reveal more on the function of GLO1.
Figure 1 shows GLO1 connected to HAGH, its partner in the glyoxalase system (see protein page). GLO1 is also coexpressed with Superoxide dismutase (SOD2), an enzyme that metabolizes superoxide [2]. Mutations in the SOD2 gene are associated with motor neuron diseases and cancer (similar to GLO1).
MAOA and MAOB, or Monoamine oxidase A and B, could be of particular interest due to their degradation of not only toxic amines in the nervous system, but also their role in breaking down dopamine. Dopamine is an essential neurotransmitter in mood regulation [3].
Figure 1 shows GLO1 connected to HAGH, its partner in the glyoxalase system (see protein page). GLO1 is also coexpressed with Superoxide dismutase (SOD2), an enzyme that metabolizes superoxide [2]. Mutations in the SOD2 gene are associated with motor neuron diseases and cancer (similar to GLO1).
MAOA and MAOB, or Monoamine oxidase A and B, could be of particular interest due to their degradation of not only toxic amines in the nervous system, but also their role in breaking down dopamine. Dopamine is an essential neurotransmitter in mood regulation [3].
References
[1] STRING (Search Tool for the Retrieval of Interacting Genes/Proteins). N.p., n.d. Web. 23 Apr. 2013.
[2] Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (December 1995). "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase". Nat. Genet. 11 (4): 376–81. doi:10.1038/ng1295-376. PMID 7493016.
[3] Depue, R. A., & Collins, P. F. (1999). Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion. Behavioral and Brain Sciences, 22, 491–517.
[2] Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (December 1995). "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase". Nat. Genet. 11 (4): 376–81. doi:10.1038/ng1295-376. PMID 7493016.
[3] Depue, R. A., & Collins, P. F. (1999). Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion. Behavioral and Brain Sciences, 22, 491–517.
Site created by: Emma Baar
Last updated: 5-14-2013
University of Wisconsin - Madison
Last updated: 5-14-2013
University of Wisconsin - Madison